Healthcare Associated Infections: The Patient & Physician's Guide

Healthcare associated infections, or HAIs, are a significant risk associated with inpatient healthcare. These infections spread in hospitals, outpatient clinics, and other healthcare facilities, and can end up making patients more ill than when they first sought treatment.

Both providers and patients should be aware of the risks associated with HAIs. Hospitalized patients are at risk of developing at least one HAI during their stay. Read on to learn more about the causes, symptoms, and prevention options for these infections, as well as when an HAI is grounds for a medical malpractice claim. The impact of HAIs on patients and the healthcare system also includes significant healthcare costs.

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What Are Healthcare Associated Infections?

A healthcare associated infection is an illness that develops while a patient receives treatment in a healthcare facility. These infections are also called nosocomial infections.

These infections can range from mild illnesses that clear up in a day, to life-threatening conditions that put patients back in the hospital. These infections spread easily in healthcare settings due to the large concentration of patients in a relatively small space.

HAIs have a major impact on both affected patients and the healthcare system as a whole. Patients may suffer serious health complications, resulting in a prolonged hospital stay and additional medical treatments. Hospitals struggle with extra costs from HAIs ranging from $28 to $45 billion.

According to the Centers for Disease Control and Prevention (CDC), on any given day, one out of every 31 hospital patients contracts an HAI. For residents of nursing homes, the rate is one in 43. Patients in surgical centers, dialysis facilities, and other settings are also at risk of HAIs. HAIs can have serious consequences, including emotional stress, financial and medical costs, prolonged hospital stays, and even death.

Iatrogenic Infection vs. Nosocomial Infection

Nosocomial infections and iatrogenic infections are both types of HAIs, and these two terms are often confused. However, they have different meanings.

When comparing iatrogenic vs. nosocomial infections, an iatrogenic infection is caused specifically by a medical procedure. Nosocomial infections are simply infections that spread in a medical setting, but are not necessarily caused by a specific treatment. Both types of infections are associated with the delivery of medical care, where various healthcare interventions and environments can contribute to the risk of infection.

For example, you could contract a nosocomial infection just by sitting near another patient who is sick. However, an iatrogenic infection could spread if healthcare workers don’t use proper hygiene procedures when preparing for surgery or administering medication.

Causative Organisms of Healthcare Associated Infections

Healthcare associated infections (HAIs) are driven by a diverse group of pathogenic microorganisms that thrive in healthcare settings. Among the most common causative organisms are methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Clostridioides difficile (C. difficile). These bacteria and other pathogens are responsible for a wide range of associated infections, including surgical site infections, urinary tract infections, bloodstream infections, and respiratory tract infections.

The National Healthcare Safety Network (NHSN) tracks the most frequent types of HAIs, such as central line-associated bloodstream infections, catheter-associated urinary tract infections, surgical site infections, and ventilator-associated pneumonia. Each of these infections is often linked to specific causative organisms. For example, MRSA and other antimicrobial-resistant pathogens are notorious for causing surgical site infections and bloodstream infections, while C. difficile is a leading cause of gastrointestinal illness in healthcare settings.

Medical devices play a significant role in the development of HAIs. The use of urinary catheters, especially indwelling urinary catheters, increases the risk of catheter-associated urinary tract infection. Similarly, central venous catheters and central lines are major risk factors for central line-associated bloodstream infections. These devices can provide a direct pathway for bacteria like Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa to enter the body, leading to serious complications.

Certain patient populations are at higher risk for healthcare associated infections. Elderly patients, individuals with chronic conditions, and those with weakened immune systems are more susceptible to infections acquired in healthcare settings. The use of antimicrobial agents can also disrupt the body’s natural defenses, making it easier for resistant organisms to take hold.

Effective infection prevention and control measures are essential to reduce the risk of HAIs. Proper hand hygiene, the use of personal protective equipment, and strict cleaning protocols for medical devices and contaminated surfaces are all critical steps. Healthcare providers must stay vigilant, follow disease control and prevention guidelines from organizations like the Centers for Disease Control and Prevention, and educate patients about infection risks and prevention strategies.

Understanding the causative organisms behind healthcare associated infections is key to improving patient safety and healthcare outcomes. By implementing robust infection control measures and fostering a culture of awareness, healthcare workers and patients can work together to minimize the threat of HAIs and protect public health.

Examples of Healthcare Associated Infections

There are four primary types of infections: bacterial, viral, fungal, and parasitic. Some of these are more common than others in healthcare settings.

Some of the most common healthcare associated infections include:

  • Bloodstream infections: When bacteria, viruses, or fungi enter the blood, they can cause septicemia (blood poisoning). These are most common among patients who need a central venous catheter to administer medications. This subtype is called a central line-associated bloodstream infection, or CLABSI. Gram-negative bacteria are common causative organisms in these infections, contributing to resistance and treatment challenges.
  • Urinary tract infections: Urinary tract infections caused by catheter use are common HAIs. The risk increases significantly with the use of an indwelling urinary catheter, as these devices can serve as a pathway for bacterial migration and biofilm formation. Catheter-associated urinary tract infections make up approximately 30% of all hospital-acquired infections.
  • Surgical site infections: After a surgical procedure, the incision wound may become infected without proper care. For example, a surgical site infection can develop at the site of a hip replacement. Surgical site infections can also affect the area around an implant, like a replacement joint or a metal rod in a bone. Wound infections are a common type of postoperative complication, often resulting from contamination during surgical procedures.
  • Ventilator-associated pneumonia: This is a lung infection that happens when air sacs swell and fill with fluids, making it difficult to breathe. It happens when patients are unable to breathe safely on their own and need ventilator treatment for an extended period of time. Ventilator-associated pneumonia typically develops after 48 hours of hospital admission and is especially common in the intensive care unit.
  • Gastrointestinal infections: Digestive tract infections spread quickly in healthcare settings. C. difficile infections are one of the most common HAIs, causing symptoms like diarrhea, fever, nausea, and cramping. These infections have a significant impact, particularly in patients with recent antibiotic use, advanced age, or prolonged hospitalization, and are associated with increased morbidity and healthcare costs.
  • Candida spp: Candida spp is a common pathogen associated with catheter-related infections and plays a significant role in central line-associated bloodstream infections (CLABSIs).
  • MRSA: One of the most common healthcare associated infection examples is methicillin-resistant Staphylococcus aureus, or MRSA. This is a staph infection known for its strong antibiotic resistance. It causes skin infections and often spreads in hospitals.

Device-related infections, such as those involving an indwelling urinary catheter, are distinct from infections that occur after a surgical procedure. Device-related infections are linked to the presence of medical devices, while procedure-related infections, like those following surgical procedures, are associated with operative interventions and wound contamination.

What Is the Most Common Cause of Healthcare Associated Infections?

Healthcare associated infections are caused by a variety of bacteria, viruses, and fungi that spread quickly in a healthcare setting. This often happens when these pathogens evolve and antimicrobial resistance develops. In this scenario, medications are no longer as effective for treating the HAI, which means they can spread faster.

Germs causing healthcare associated infections may be transmitted by direct skin-to-skin contact with other people or with contaminated surfaces. Some healthcare associated infections are spread by air when people sneeze or cough, as respiratory droplets are a primary means of transmission for certain pathogens.

How Are Healthcare Associated Infections Spread?

Healthcare associated infections are most often spread by direct physical contact or breathing in airborne particles. Here are some of the specific risk factors for healthcare associated infections:

  • Contaminated equipment: Blood pressure cuffs, thermometers, wheelchairs, and other equipment shared among patients may transmit HAIs if they are not disinfected between uses.
  • Contaminated environment: Frequently touched parts of hospital rooms, like tray tables, light switches, and bed rails, may harbor bacteria and viruses.
  • Improper hand hygiene: Research shows that contamination of healthcare workers’ hands causes nearly one-third of HAIs (30%).
  • Antibiotic resistance: Antibiotics are medicines that kill bacteria, but some bacteria have evolved to survive them. The antibiotic-resistant bacteria may cause outbreaks of HAIs.
  • Prolonged hospital stays: Research shows that people who have more extended hospital stays are more likely to contract an HAI.
  • Invasive procedures: Procedures that involve breaking the skin (like surgery) or inserting something in the body (like a catheter) may introduce pathogens that could lead to an infection.
  • Weakened immune systems: People with weakened immune systems are less able to fight off viruses and bacteria.

Symptoms & Diagnosis

The exact symptoms of an HAI will depend on the specific infection present. Here are some of the most common symptoms of these infectious diseases.

  • Fever: Defined as a body temperature of 100.4°F or higher, this is a common symptom of many HAIs.
  • Severe pain: Infections can cause persistent aches and pains. For example, C. difficile infections often cause abdominal pain, while surgical site infections cause discomfort around the incision.
  • Urinary changes: Urinary tract infections lead to painful urination, the need to urinate more often than normal, and even blood in the urine in severe cases.
  • Skin changes: Staph infections like MRSA can cause red, swollen rashes.
  • Diarrhea: C. difficile infections and other gastrointestinal illnesses often lead to diarrhea and other digestive problems.
  • Breathing problems: Hospital-acquired pneumonia and other respiratory infections often cause difficulty breathing and persistent coughs.
  • Bloodstream infections: Central line-associated bloodstream infections (CLABSI) can cause chills, fever, and low blood pressure. In severe cases, these infections can progress to septic shock.

To diagnose these infections, doctors will start by asking detailed questions about the patient’s symptoms and conducting a thorough physical exam. Clinical signs, along with symptoms and diagnostic tests, are used to confirm healthcare associated infections (HAIs).

If they suspect the patient has an HAI, they will order a lab test to confirm the presence of pathogenic bacteria, viruses, or fungi. Depending on the type of HAI the physician suspects, they may order blood tests, urine tests, stool tests, or sputum (phlegm) tests. With the results of these tests, doctors can recommend appropriate treatment.

Preventing Healthcare Associated Infections

Research shows that as many as 70% of HAIs could be prevented with evidence-based control methods. Here are some of the ways that providers and patients can prevent HAIs in clinical settings.

  • Strict hand hygiene protocols: Since healthcare associated infections are most often spread by direct contact, providers need to keep their hands clean at all times. The Centers for Disease Control and Prevention recommends that providers clean their hands both before and after touching patients. They may need to clean their hands as many as 100 times per shift with hand sanitizer or soap and water.
  • Sterilization of medical equipment: All equipment that has come in contact with body tissues or fluids, like surgical tools, must be sterilized to remove body fluids and kill infection-causing viruses and bacteria.
  • Environmental cleaning: Regular cleaning and disinfecting of patient areas may lower the rates of HAIs, studies have shown. That includes cleaning floors, beds, doorknobs, and other surfaces for infection prevention.
  • Improving antibiotic practices: About a third of antibiotics prescribed in U.S. hospitals are unnecessary. The misuse of this medication leads to antibiotic resistance, so hospitals should implement programs to ensure drugs are prescribed appropriately. Hospitals should also implement systematic review of antimicrobial agents to identify when pathogens are evolving and becoming resistant.
  • Educating patients: Educating patients and their families is essential for infection control. Healthcare professionals should inform and guide patients about risk factors, preventive practices such as good hand hygiene, proper device care, and the correct use of antibiotics to reduce the risk of healthcare associated infections. Patients should also be educated about infection warning signs to watch for.
  • Isolation precautions: To reduce the risk of spread, keeping patients with suspected or confirmed HAIs separate from other patients is key. Reusable equipment (like blood pressure cuffs) should be dedicated to a single isolation patient. Hospitals may also isolate immunocompromised patients to reduce their risk.

The Role of Healthcare Providers

So how can surgeons help to limit nosocomial infections? Adhering to strict hygiene and patient safety protocols is key to infection control.

Surgeons, physicians, nurses, and other healthcare professionals should practice good hand hygiene at all times, even during busy periods. Many healthcare workers are already prioritizing hand hygiene, but there is room for improvement with hand washing compliance hovering around 50% at U.S. hospitals.

Surgical errors can also lead to life-threatening infections. To prevent this, surgeons should always use multiple patient identifiers to confirm their identity before starting the procedure, and mark the designated site clearly before the patient undergoes anesthesia.

Continuing education can also help providers stop the spread of HAIs. Healthcare organizations should offer regular infection prevention courses for their teams, especially those working in high-risk areas like intensive care units.

Infection Control Measures

Infection control measures are crucial in preventing the spread of healthcare associated infections (HAIs). Hand hygiene is the most important practice in preventing HAIs. Healthcare workers should wash their hands with soap and water or use an alcohol-based hand rub before and after interacting with patients. This simple yet effective practice can significantly reduce the transmission of pathogens.

Sterilization of equipment and surfaces is also necessary to prevent the spread of HAIs. All medical equipment that comes into contact with body tissues or fluids must be thoroughly sterilized to kill any potential pathogens. Regular cleaning and disinfecting of patient areas, including floors, beds, doorknobs, and other surfaces, can lower the rates of HAIs.

Isolation protocols, such as placing patients with infectious diseases in private rooms, can help prevent the spread of HAIs. Healthcare facilities should have policies in place for the proper use of personal protective equipment (PPE), such as gloves and masks, to prevent the spread of infections. By adhering to these infection control measures, healthcare workers can protect patients and themselves from HAIs.

Antimicrobial Stewardship

Antimicrobial stewardship is a critical component of infection control measures. It involves the appropriate use of antibiotics to prevent the development of antibiotic-resistant bacteria. Healthcare providers should only prescribe antibiotics when necessary and should choose the most effective antibiotic for the specific infection.

Healthcare facilities should have policies in place for monitoring and reporting antibiotic use and resistance. This can help prevent the spread of multidrug-resistant infections, such as methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile (CDI).

Patient Education & Empowerment

Patients and their families should be educated on the risks of HAIs and the steps they can take to prevent them. When entering an inpatient facility, all patients should receive information about hygiene and medication best practices. Guide patients on how to wash their hands, when to take their medication, and how to use medical devices if they have them.

If the patient has surgery, they should receive guidance on how to change their bandages and clean the incision safely, as well as possible infection symptoms to watch for. When possible, schedule follow-up appointments to ensure the wound is healing safely.

Encourage patients to ask questions about their procedures and to report possible symptoms as soon as they arise. When communicating with patients about HAIs, be as clear and transparent as possible, and explain concepts in layman's terms rather than medical jargon.

Be honest with patients about the potential risks of HAIs in healthcare settings, and be sure to obtain informed consent whenever necessary. Patient education materials, such as brochures or fact sheets, may help address HAI concerns with patients. Physicians can also suggest reputable online resources, such as government websites like CDC.gov and MedlinePlus.gov.

Ultimately, it’s important to remember that HAIs are often preventable but present a potentially serious risk of harm to patients. Healthcare associated infections are mostly spread by direct contact with pathogens, meaning many are preventable.

By focusing on awareness and prevention, healthcare facilities can promote a culture of patient safety and reduce the threat of HAIs. Physicians should consider taking advantage of the risk management resources offered by their medical malpractice provider.

How Do Healthcare Associated Infections Impact Patient Outcomes?

HAIs negatively impact patient outcomes, leading to an increase in medical complications, an increased mortality rate, and higher costs for healthcare providers. In the United States, around 99,000 people die from HAIs each year.

The cost of healthcare associated infections is also significant. Estimated costs range from $28 to $45 billion annually. Hospitals and insurers bear much of this cost. HAIs can also lead to longer hospital stays, which significantly increases out-of-pocket costs for patients.

Legal Aspects: Can a Physician Be Sued for HAIs?

Just because a patient contracts an HAI in the hospital doesn’t mean a patient has been a victim of medical negligence. Bad outcomes sometimes happen, without anyone being at fault. However, it’s useful for physicians just to be reminded about how an HAI might be grounds for a medical malpractice case.

In summary, four elements must be present:

  1. Duty of care: If a doctor-patient relationship exists, the doctor owes a duty of care to the patient. That includes the duty to provide at least the accepted medical standard of care, meaning the type of care a prudent, similarly skilled doctor would offer in similar circumstances.
  2. Breach of duty of care: Doctors may breach the duty of care if they provide treatment that falls below the accepted medical standard. For example, neglecting to follow infection control protocols or failing to diagnose an HAI could be a breach.
  3. Causation: Proving causation means showing that a breach of the duty of care directly caused or worsened the HAI. That involves proving that the infection or its complications wouldn’t have happened in the absence of negligence.
  4. Damages: Finally, it must be proven that the patient suffered actual harm, i.e. harm that would not have occurred in the absence of negligence. Examples of harm include financial costs like medical expenses and lost wages, or non-economic costs like pain and suffering.

Although like most medical malpractice claims, the physician prevails most of the time, there have been occasions where a patient has successfully pursued an HAI claim and been awarded significant judgments. For example, in 2023, a New York jury awarded a man $250,000 after finding he was mistakenly prescribed an antibiotic that caused him to develop a C. diff infection. The same year, a Michigan jury awarded almost $10 million to the estate of a woman who developed a surgical wound infection and later passed away.

The Role of Malpractice Insurance in HAI Cases

Insurance helps protect physicians and other medical professionals if a patient files an HAI-related medical malpractice lawsuit. It helps cover the legal costs of defending a medical malpractice claim, including attorney, court, and expert witness fees.

Medical malpractice insurance also helps cover the costs of resolving a lawsuit. That could include the cost of an out-of-court settlement or the cost of court-awarded damages following a trial. This crucial coverage helps protect physicians’ personal finances and the finances of their practice.

How Indigo Can Help

Indigo is a revolutionary medical malpractice insurance provider that helps physicians get the coverage they need, at the price they deserve. With the power of AI, physicians receive pricing tailored to their practice and easy access to coverage. Physicians also enjoy access to a third-party risk management helpline to receive confidential advice about managing the risk of HAI lawsuits.

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Disclaimer: This article is provided for informational purposes only. This article is not intended to provide, and should not be relied on for, legal advice. Consult your legal counsel for advice with respect to any particular legal matter referenced in this article and otherwise.

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